A virus that infects 90% of people appears to be the cause of multiple sclerosis, an autoimmune disease that affects the brain. This is the conclusion of a recent study published in ScienceHe was the first to provide strong evidence for a causal relationship between viral infection and multiple sclerosis.
For years, scientists have been collecting clues that aVery common, Epstein-Barr (EBV) is believed to be the primary cause of An autoimmune disease that affects the nervous system. About 90% of the world’s population is infected with EBV, often during or the . On the other hand, the en plaque concerns only 100,000 young people in France with approximately 5,000 new cases each year.
Article published on January 13, 2022 inHe was the first to provide evidence There is a causal relationship between infection with EBV and the emergence of . « This is a big step forward because it suggests that most cases of multiple sclerosis can be prevented by preventing EBV infection, and targeting EBV could lead to the discovery of a cure for sclerosis. ‘,” explains Alberto Ashrio, a Harvard University scientist and director of the work published in Science.
New results added to the old
This study was made possible thanks to the rich collection of blood samples from the US Army. Thus, the researchers were able to obtain blood samples from 10 million young soldiers on duty, taken between 1993 and 2013. Among them, 955 cases of multiple sclerosis were diagnosed. All but one wasThe fight against EBV in in their time .
From this data, the researchers estimated that individuals with EBV are 32 times more likely to develop multiple sclerosis. EBV is not the only virus tested in blood samples, but it is the only virus that increases the risk of developing multiple sclerosis. scabbard wreckwho destroyed it B in multiple sclerosis, appears in the serum only after seroconversion to EBV.
These new results are in the same direction as other results obtained previously. In October 2021,the Infectious, caused by EBV, such as Multiple sclerosis in siblings. They conclude that having infectious mononucleosis during childhood or adolescence (between the ages of 11 and 19) increases the risk of developing multiple sclerosis from age 20. The risk appears to be greater during (11-15 years) and disappears completely after 25 years.
A mechanism that has not yet been explored
How can a virus cause aFrom the nervous system? In people with multiple sclerosis, active B cells circulating in the blood travel through the blood vessels to attack the insulating sheath, myelin, that surrounds the blood. From . However, the latter is necessary for the correct transmission of . The gradual disappearance of It causes motor, perceptual, visual and balance disturbances that vary greatly among patients.
Several hypotheses are being studied to explain how EBV can lead to this– Nothing has been confirmed yet. EBV is a family virus which infects B cells in the oropharynx using their surface receptor CD21 such as Access. the to me of the virus in the cell nucleus, along with our own genome, so that an infected person remains infected throughout their life.
EBV causes diseases other than mononucleosis in healthy people, including, From Characterized by abnormal proliferation of lymphocytes, such as Burkitt’s lymphoma or Hodgkin’s disease. In the case of multiple sclerosis, some believe that EBV-infected B cells may be responsible for the symptoms.
EBV treatment to prevent multiple sclerosis?
Although EBV appears to be the cause of multiple sclerosis, it is not sufficient for the disease to spread.. Scientists know that tobacco, During adolescence, a deficiency of or even One of the factors that contribute to the emergence of multiple sclerosis.
With these findings, a tremendous hope emerges: a cure for multiple sclerosis. Current treatments can slow the progression of the disease, but they do not prevent its long-term progression. Preventing EBV infection with a vaccine or antiviral seems like a natural solution. ” Currently, there is no effective way to prevent or treat EBV infection, but there is no vaccine or medication for EBV.May prevent or treat multiple sclerosis Alberto Ashrio concludes. calendar coincidence, EBV Vaccine Clinical Trials Started Using Technology .