Track – A large drug agency study, published on Tuesday, confirmed the safety of the Pfizer and Moderne vaccines. In contrast, the Adenovirus, AstraZeneca and Janssen vaccines “are associated with a small increase in the risk of myocardial infarction and pulmonary embolism in adults within two weeks of injection.”
This study emphasizes the balance of benefits and risks for vaccines against Covid-19. Published by the Medicines Agency on Tuesday, it shows that messenger RNA vaccines (Pfizer and Moderna) do not increase the risk of serious cardiovascular disease (heart attack, stroke, or pulmonary embolism) in people younger than 75.
As part of the booster vaccine monitoring system, Epi-Phare, a body that links the Health Insurance (Cnam) and the Medicines Agency (ANSM), conducted a study of the risk of developing serious cardiovascular diseases (excluding myocarditis and pericarditis) within three weeks of injection. From the mRNA or adenovirus vaccine.
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This study focused on all adults aged 18 to 74, whether or not vaccinated, who were admitted to hospital in France between 27 December 2020 and 20 July 2021 due to acute myocardial infarction, stroke, haemorrhage or pulmonary embolism.
Slightly higher risk with adenovirus vaccines
And its results confirm mRNA vaccine safety (Those of Pfizer and Moderna) “In relation to the risk of serious cardiovascular disease in adults” which can occur within three weeks of the first or second dose of vaccines.
In contrast, adenovirus vaccines (those from AstraZeneca and Janssen) appear “Associated with a small increase in the risk of myocardial infarction and pulmonary embolism in adults within two weeks of injection”. We estimate that the risk of pulmonary embolism and acute myocardial infarction will increase to about 30% during the second week after the first dose. (from AstraZeneca)”, according to the authors. As for Janssen’s vaccine, it is of little use in France, “Estimation is more uncertain due to lower total number of cases”.
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These two adenovirus vaccines are not widely used in France, ANSM recalls. The risk of atypical venous thrombosis is associated with young adults, and health authorities recommend only those people over 55 years of age.
Key finding confirms safety of messenger RNA vaccines in people under the age of 75
“For us, this is a key finding that confirms the safety of mRNA vaccines in people under the age of 75,” Our colleagues from AFP told Rosemary Dry-Spera, an epidemiologist and deputy director of Epi-Phare Structure.
Request from our colleagues from GlobalismMatthew Mollemare, MD, chief of medical pharmacology at Purdue University Hospital, agrees. “This study needs to be put into perspective with the risk of cardiovascular events in people with Covid-19. Because we have to take into account the fact that everyone will get this disease, whether using the Omicron variant or others. And the risk is greater with the disease than with vaccines, especially Those that contain messenger RNA, which prove to be extremely safe from study to study.”, Confirms.
Covid disease itself is associated with a risk of cardiovascular complications
This survey is corroborated by other international studies. A previous study, which focused on people aged 75 or older, did not show an increased risk of cardiovascular disease after every two doses of Pfizer’s vaccine.
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Another Epi-Phare study in people aged 12 to 50 showed that Pfizer vaccines and especially Moderna vaccines increased the risk of developing myocarditis or pericarditis occurring within 7 days of vaccination, more often in men who They are under 30 years old.
Closely related to the risk of cardiovascular complications, Covid-19, also likes to call the ANSM.
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